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Research partners and projects

Over 30 universities and institutions have conducted research using our digital health platform, and we're a technical partner in several research projects. Here, we highlight a few of these studies and validation projects. If you're interested to know more about any of the research conducted with our platform, please let us know.


In progress



In 2024, we are starting an RCT on the effectiveness of our German DiGA module 'Mein Wegbegleiter'.

Living with physical complaints

Dutch mental health institution GGZ Breburg is preparing a study on the module ‘Grip op een leven met lichamelijke klachten’ (Getting to grips with living with physical complaints).

Dealing with aggression

Hanneke Kip is a PhD student at the Dutch University of Twente and at Transfore, forensic care institution. She researches the effectiveness of the module ‘Omgaan met agressie’ (Dealing with aggression).

Read more about Hanneke Kip and this research.

Acceptance and Commitment Therapy: From complaint to resilience

Tim Batink is the Dutch developer of the validated method 'ACT: Van Klacht naar Veerkracht' (From complaint to resilience). Together with Minddistrict, he developed the method into a guided ehealth module. Currently, research is being conducted through the Open University on the effectiveness of this module.


Mind-RENA is a fully digital and guided German aftercare programme that supports people after their psychosomatic rehabilitation course has ended. The programme consists of the Mind-RENA module and online moments of contact with a supervising therapist. Developed by clinical experts and patients together, the programme is currently being studied for effectiveness in an RCT.

GILL ehealth

Researchers at Amsterdam UMC are studying the effectiveness of the GILL ehealth intervention - a practice- and evidence-based tool that integrates somatic screening and lifestyle promotion for patients with severe mental illness (SMI).


An RCT on the module Mindresolve module was completed in 2017.

  • Topper, M., Emmelkamp, P. M., Watkins, E., & Ehring, T. (2017). Prevention of anxiety disorders and depression by targeting excessive worry and rumination in adolescents and young adults: A randomised controlled trial. Behaviour research and therapy, 90, 123–136.
  • Or read the online publication

A second RCT on MindReSolve was completed in 2019, by the name of RESPOND.

  • Cook, L., Mostazir, M., & Watkins, E. (2019). Reducing Stress and Preventing Depression (RESPOND): Randomized Controlled Trial of Web-Based Rumination-Focused Cognitive Behavioral Therapy for High-Ruminating University Students. Journal of medical Internet research, 21(5), e11349.
  • Or read the online publication

Acquired brain injury and insomnia

The Dutch rehabilitation organisation Heliomare developed the module ‘NAH en slaap-waakproblemen' (Acquired brain injury and insomnia). They investigated its efficacy through an RCT that was published in 2022.

  • Ford, M. E., Geurtsen, G. J., Groet, E., Rambaran Mishre, R. D., Van Bennekom, C., & Van Someren, E. (2022). A blended ehealth intervention for insomnia following acquired brain injury: a randomised controlled trial. Journal of sleep research, e13629.
  • You can read the study online in the Journal of sleep research


The Dutch i-Sleep module was developed and researched by staff from the Department of Clinical Psychology at the VU University of Amsterdam. It is available for Minddistrict customers to use (in Dutch).

  • Dozeman, E., van Straten, A., van Genugten, C. R., & van Schaik, D. J. F. (2019). Begeleide web-based interventie voor slaapproblemen (I-Sleep) bij patiënten met een depressie in de ambulante gespecialiseerde ggz: Een pilotstudie (Guided web-based intervention for sleeping problems (I-Sleep) in depressed patients within outpatient specialist mental health care: A pilot study). Tijdschrift voor Psychiatrie, 61(10), 683–691.
  • Or read the study in Dutch on the website of VU University Amsterdam


Systems Training for Emotional Predictability and Problem Solving for Emotional Intensity (STEPPS-EI) is a practical, evidence-based intervention for people who experience difficulties managing intense emotions. Sussex Partnership NHS Foundation Trust (SPFT) developed a digital group intervention for blended use, which they then researched on effectiveness. The intervention is available on the Minddistrict ehealth platform. Read more about the STEPPS-EI intervention and our partnership with SPFT on this project.

  • Barber, W., Apps, F., Strauss, C., Startup, H., & Couche, J. (2021). Subthreshold personality disorder: How feasible is treatment in primary care? The Cognitive Behaviour Therapist, 14, E12.
  • Or read the article online in the Cognitive Behaviour Therapist
  • The study on the efficacy of the online intervention can be read at Procedia Computer Science

MS Fit

MS Fit was developed within the Department of Medical Psychology at Amsterdam UMC. This blended intervention is based on an evidence-based face-to-face protocol for CBT for MS-related fatigue. Research shows that MS Fit is effective in reducing fatigue in MS patients. The treatment has proven to be time-efficient: it costs therapists less time compared to the face-to-face treatment, with the same results.

de Gier, M., Beckerman, H., Twisk, J., Knoop, H., & de Groot, V. (2023). Blended versus face-to-face cognitive behavioural therapy for severe fatigue in patients with multiple sclerosis: A non-inferiority RCT. Multiple Sclerosis Journal, 13524585231185462.

Depression treatment

2019 saw the publication of the RCT on the effectiveness of blended use of our Depression module.

  • Kooistra, L. C., Wiersma, J. E., Ruwaard, J., Neijenhuijs, K., Lokkerbol, J., van Oppen, P., Smit, F., & Riper, H. (2019). Cost and Effectiveness of Blended Versus Standard Cognitive Behavioral Therapy for Outpatients With Depression in Routine Specialized Mental Health Care: Pilot Randomized Controlled Trial. Journal of Medical Internet Research, 21(10), e14261.

  • Kooistra, Ruwaard, Wiersma, van Oppen, & Riper. (2020). Working Alliance in Blended Versus Face-to-Face Cognitive Behavioral Treatment for Patients with Depression in Specialized Mental Health Care. Journal of Clinical Medicine, 9(2), 347.

Online Tics: Training

Medizinische Hochschule Hannover (MHH) developed and researched a (German) module for people with tic disorder using the Minddistrict content management system.

  • Haas, M., Jakubovski, E., Kunert, K., Fremer, C., Buddensiek, N., Häckl, S., Lenz-Ziegenbein, M., Musil, R., Roessner, V., Münchau, A., Neuner, I., Koch, A., & Müller-Vahl, K. (2022). ONLINE-TICS: Internet-Delivered Behavioral Treatment for Patients with Chronic Tic Disorders. Journal of Clinical Medicine, 11(1), 250.

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